Veteran’s Administration I01 BX005118 PI: Tasker 2021-2024
Title: Role of amygdala inhibitory circuit neuromodulation in stress disorders
Goal: To determine the role of defined inhibitory synaptic circuits in the basolateral amygdala in fear conditioning and in traumatic stress-induced deficits in fear memory acquisition and extinction.
NIH/NIDDK R01 DK118292 PI: Yve Ulrich-Lai, Co-I: Tasker 05/08/2020 – 04/30/2022
Title: Stress, comfort food, and obesity
Goal: To determine the mechanisms in the basolateral amygdala responsible for sucrose dampening of the stress response.
NIH/NIMH R01 MH119283 PI: Tasker 08/01/2019-05/31/2024
Title: Stress plasticity of CRH neurons
Goal: To determine the cellular mechanisms responsible for the glucocorticoid-induced α1 adrenoreceptor desensitization and the physiological and behavioral significance of the stress plasticity of the noradrenergic innervation of PVN CRH neurons.
NIH/NCATS UG3 TR003150 PI: Moore, Co-I: Tasker 09/26/2019-07/31/2021
Title: Human Microphysiological Model of Afferent Nociceptive Signaling
Goal: To develop a 3-D microphysiological system to model the first afferent synapse of the pain pathway in the dorsal horn of the spinal cord.
NIH/NIAAA 1R01AA026531-01 Multi-PI: Tasker, Gilpin (LSU) 09/15/2017-07/31/2022
Title: Traumatic Stress Increases Alcohol Drinking via Endocannabinoid Disinhibition of Basolateral Amygdala
Goal: To compare endocannabinoid mechanisms at GABAergic synapses in rats that avoid the stress context and escalate alcohol consumption following traumatic stress exposure with non-avoider, non-escalator rats.
NIH/NIMH 1R01MH104373-01A1 PI: Tasker 04/01/2015-12/31/2019 (NCE to 12/20)
Title: Stress Facilitation of Fear Memory: Cellular Mechanisms
Goal: To determine whether stress facilitates fear memory formation by a rapid glucocorticoid-induced endocannabinoid mechanism mediated by activation of membrane glucocorticoid receptors in the basolateral amygdala.